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How anthropogenic forcing could change tropical cyclones (TCs) is a keen societal concern owing to its significant socio-economic impacts. However, a global picture of the anthropogenic aerosol effect on TCs has not yet emerged. Here we show that anthropogenic aerosol emission can reduce northern hemisphere (NH) TCs but increase southern hemisphere (SH) TCs primarily through altering vertical wind shear and mid-tropospheric upward motion in the TC formation zones. These circulation changes are driven by anthropogenic aerosol-induced NH-cooler-than-SH and NH-increased versus SH-decreased meridional (equator to mid-latitudes) temperature gradients. The cooler NH produces a low-level southward cross-equatorial transport of moist static energy, weakening the NH ascent in the TC formation zones; meanwhile, the increased meridional temperature gradients strengthen vertical wind shear, reducing NH TC genesis. The opposite is true for the SH. The results may help to constrain the models’ uncertainty in the future TC projection. Reduction of anthropogenic aerosol emission may increase the NH TCs threat.